Publications
Publications
2022-2015
2022
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A: Nature Communications 2022;13(1):7648.
DOI: 10.1038/s41467-022-35331-0
Kattner L, Rauch E: Synthesis of 13C Labeled Vitamin D Metabolites for Their Use in LC-MS/MS: Valuable Tools for Cancer Research and Other Applications. Anticancer Res. 2022;42: 5077-5081. DOI: 10.21873/anticanres.16016
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Kattner L: Novel approach to A-ring synthon for Pd-catalyzed synthesis of 1α-hydroxylated vitamin D metabolites. J Steroid Biochem Mol Biol. 2022;
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Loureiro J, Kattner L, Mouriño A: Efficient Asymmetric Synthesis of an A‐Ring Synthon for Pd‐Catalyzed Preparation of 1α‐Hydroxyvitamin D Metabolites and Analogs. Europ J Org Chem. 2022;
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Putkaradze N, Abdulmughni A, Ilona K. Jóźwik IK, Kattner L, Zapp J, Hutter MC, Frank Hannemann F, Andy-Mark W.H. Thunnissen AMWH, Bernhardt R: Functional and structural characterization of cholesterol-,vitamin D 2 - and D 3 – hydroxylases from bacillus megaterium. Anticancer Res. 2022;42:2195.
Kattner L: Synthesis of 13C-labelled vitamin D metabolites for their use in LC-MS/MS applications. Anticancer Res. 2022;42:2203.
2020
Mäder P, Kattner L: Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry. J. Med. Chem. 2020, 63, 23, 14243–14275
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Kattner L, Rauch E: Efficient synthesis of 3-TBDMS-11α,25-dihydroxyvitamin D3 and D2 ethers. J Steroid Biochem Mol Biol. 2020;200: 105638.
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Putkaradze N, König L, Kattner L, Hutter MC, Bernhardt R: Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1. Biochem Biophys Res Commun 2020;524(2):295-300
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Kattner L, Rauch E: Recent developments towards the synthesis of vitamin D metabolites. Anticancer Res 2019;39:3280-3281.
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2019
Kattner L: Recent developments towards the synthesis of vitamin D metabolites. Anticancer Res 2020;40:519-525.
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Mäder P: Boron in Medicinal Chemistry: Powerful, but Neglected, CHIMIA 2019, 73, No. 7/8
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2018
Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine 2018;10:eaan0724.
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2017
Mohamed, B. A., Kattner, L., Guan, K., Lehnart, S. E., Luther, S., Sossalla,S., et al.: The relevant role of SR Ca leak in the development of heart failure. European Journal of Heart Failure 2017; 19(Suppl_1): 343-343.
Kattner L, Bernardi D: An Efficient Synthesis of 1alpha,25-Dihydroxyvitamin D3 LC-Biotin. J Steroid Biochem Mol Biol. 2017;173:89-92.
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Kattner L, Volmer DA: Synthesis of Low Abundant Vitamin D Metabolites and Assaying Their Distribution in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) as a New Tool for Diagnosis and Risk Prediction of Vitamin D related Diseases In: A Critical Evaluation of Vitamin D - Basic Overview, Sivakumar Gowder (editor), Intech publishers, Rijeka. 2017;103-127. ISBN 978-953-51-3084-0.
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Flyer: Your partner for vitamin D synthesis
2016
Kattner L, Rauch E: Optimization of Chemical Syntheses of Vitamin D C3-Epimers. Anticancer Res 36(3):1417-1422, 2016.
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3rd Compass to Europe´s Innovative Chemical Companies
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2015
Kattner L, Bernardi D, Rauch E: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products. Anticancer Res 35(2):1205-1210, 2015.
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2014-2007
2014
Azimi Hashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF: Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications (5):1-12, 2014.
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2013
Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, Kattner L, El-Armouche A, Eschenhagen Th: Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches. J Biomol Screen 18(8):899-909, 2013.
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Bourgonje VJ, Vos MA, Ozdemir S, Doisne N, Acsai K, Varro A, Sztojkov-Ivanov A, Zupko I, Rauch E, Kattner L, Bito V, Houtman M, van der Nagel R, Beekman JD, van Veen TA, Sipido K, Antoons G: Combined Na+/Ca2+ Exchanger and L-Type CalciumChannel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function. Circulation: Arrhythm Electrophysiol. 6:371-379, 2013.
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Scholz T, Heyl CL, Bernardi D, Zimmermann S, Kattner L, Klein CD: Chemical, Biochemical and Microbiological Properties of a Brominated Nitrovinylfuran with Broad-Spectrum Antibacterial Activity. Bioorg Med Chem, 21:795-804, 2013.
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2009
Steuer Ch, Heinonen KH, Kattner L, Klein CD: Optimization of assay Conditions for Dengue Virus protease. Effect of various Polyols and Nonionic Detergents. J Biomol Screen. 14(9):1102-1108, 2009.
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Poster “Frontiers in Medicinal Chemistry”, Heidelberg: Identification of Lead Compounds for Dengue NS3 Protease Inhibitors.
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Sotoud H, Kattner L, Eschenhagen Th, El-Armouche A Colorimetric protein phosphatase inhibition assay for specific detection of phosphatase-inhibitor-1 inhibitory compounds Archiv für Experimentelle Pathologie und Pharmakologie 2009.
2008
Holzer M, Ziegler S, Albrecht B, Kronenberger B, Kaul A, Bartenschlager R, Kattner L, Klein CD, Hartmann RW: Identification of Terfenadine as an Inhibitor of Human CD81-receptor HCV-E2 Interaction: Synthesis and Structure Optimization. Molecules.13:1081-1110, 2008.
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2007
Outsourcing of medicinal chemistry in the drug discovery process faces CRO´s and pharmaceutical companies with challenges. PharmChem. 2007, July/August, 6-7.
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