Endotherm GmbH, an ISO9001:2015 certified contract research organization (CRO), has an outstanding technology platform available to be applied to the synthesis of rare stable isotopically labelled (13C, 2H, 15N) reference materials (biomarkers, reference standards, calibrators, controls) to be used in clinical chemistry applications, such as HPLC- or LC-MS/MS based therapeutic drug monitoring.

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Particularly, as demonstrated by own patents and high-impact peer-reviewed publications, the company has a unique expertise available to provide the synthesis of vitamin D metabolites to be used for the development of immunological or LC-MS/MS based assays towards the diagnosis of vitamin D related diseases.

Additionally, the outstanding technology of the company applies to the synthesis of fluorescent dyes to be used for screening campaignes in medicinal chemistry research, laboratory samples of APIs (Active Pharmaceutical Ingredients) for the approval of drugs, along with any small molecules, such as natural products and various metabolites or intermediates, not otherwise commercially available or high priced.

Finally, the company is executing own research projects in medicinal chemistry, aiming to discover new therapeutics against infectious diseases (Dengue, Hepatitis C, bacterial infections with multiresistant strains), heart diseases (heart failure, arrhythmias), kidney diseases (PKD) and posttraumatic stress disorder (PSD).

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Highlighted publications and patents

Mäder P, Kattner L: Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry. J. Med. Chem. 2020, 63, 23, 14243–14275. doi/10.1021/acs.jmedchem.0c00960

Kattner L, Rauch E: Efficient synthesis of 3-TBDMS-11α,25-dihydroxyvitamin D3 and D2 ethers. J Steroid Biochem Mol Biol. 2020;200:105638. DOI: 10.1016/j.jsbmb.2020.105638

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine 2018;10:1-11. DOI: 10.1126/scitranslmed.aan0724

Kattner L, Volmer DA. Book Chapter: Synthesis of low abundant vitamin D metabolites and assaying their distribution in human serum by liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a new tool for diagnosis and risk prediction of vitamin D related diseases. In: Gowder S, editor. A critical evaluation of vitamin D - basic overview, 1st ed. Rijeka: Intech publishers; 2017. P. 103-127. ISBN 978-953-51-3084-0.

Azimi Hashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF: Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications 2014;5:1-12.