{"id":27199,"date":"2022-04-28T14:11:36","date_gmt":"2022-04-28T12:11:36","guid":{"rendered":"https:\/\/endotherm-lsm.com\/auftragssynthesen\/klinische-chemie"},"modified":"2023-05-26T17:01:45","modified_gmt":"2023-05-26T15:01:45","slug":"klinische-chemie","status":"publish","type":"page","link":"https:\/\/endotherm-lsm.com\/en\/auftragssynthesen\/klinische-chemie","title":{"rendered":"Clinical chemistry"},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull is-light page__header\" style=\"min-height:300px\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\"><\/span><img decoding=\"async\" loading=\"lazy\" width=\"2437\" height=\"812\" class=\"wp-block-cover__image-background wp-image-24994\" alt=\"\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035.jpg\" style=\"object-position:50% 43%\" data-object-fit=\"cover\" data-object-position=\"50% 43%\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035.jpg 2437w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-300x100.jpg 300w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-600x200.jpg 600w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-1024x341.jpg 1024w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-768x256.jpg 768w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-1536x512.jpg 1536w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/10\/ENDOTHERM_2_2200035-2048x682.jpg 2048w\" sizes=\"(max-width: 2437px) 100vw, 2437px\" \/><div class=\"wp-block-cover__inner-container\">\n<h1 class=\"wp-block-heading page__title has-accent-color has-text-color\">Clinical chemistry<\/h1>\n<\/div><\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-2 wp-block-columns md__padding\">\n<div class=\"is-layout-flow wp-block-column col-10 text\" style=\"flex-basis:83.333333333333%\">\n<h2 class=\"wp-block-heading\">Reference material synthesis<\/h2>\n\n\n\n<p>Diagnostics companies are constantly challenged with new complex requirements for clinical chemistry, not least due to everchanging and increasingly stringent in vitro diagnostics (IVD) guidelines. For this reason, companies prefer to rely exclusively on contract synthesis companies like Endotherm Life Science Molecules to provide the necessary active ingredients and biomarkers used as reference standards for the development of diagnostic immunological and HPLC- as well as LC-MS\/MS-based test systems. Our focus in this arena is on unlabeled or labeled (<sup>2<\/sup>H, <sup>13<\/sup>C, <sup>15<\/sup>N) vitamin D metabolites, active pharmaceutical ingredients (API), and natural products.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-6 wp-block-columns sm__gap md__padding lg\">\n<div class=\"is-layout-flow wp-block-column whitebox area\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full border\"><img decoding=\"async\" loading=\"lazy\" width=\"320\" height=\"240\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/09\/header-start-ENDOTHERM_1_00064_320px.jpg\" alt=\"\" class=\"wp-image-15953\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/09\/header-start-ENDOTHERM_1_00064_320px.jpg 320w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/09\/header-start-ENDOTHERM_1_00064_320px-300x225.jpg 300w\" sizes=\"(max-width: 320px) 100vw, 320px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-center has-base-color has-text-color\">Vitamin D diagnostics<\/h4>\n\n\n\n<p class=\"has-text-align-center\">Vitamin D is gaining clinical importance in diagnostics. Endotherm owns proprietary and patented synthesis processes for the production \u2026<\/p>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"#vitamind-diagnostik\">read more<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"is-layout-flow wp-block-column whitebox area\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full border\"><img decoding=\"async\" loading=\"lazy\" width=\"400\" height=\"300\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/refmaterial-ENDOTHERM_1_00023.jpg\" alt=\"\" class=\"wp-image-2233\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/refmaterial-ENDOTHERM_1_00023.jpg 400w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/refmaterial-ENDOTHERM_1_00023-300x225.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-center has-base-color has-text-color\">Therapeutic Drug-Monitoring<\/h4>\n\n\n\n<p class=\"has-text-align-center\">Reference standards are indispensable for the development of diagnostic methods \u2026<\/p>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"#wirkstoffe-referenzstandards\">read more<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"is-layout-flow wp-block-column whitebox area\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full border\"><img decoding=\"async\" loading=\"lazy\" width=\"320\" height=\"240\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/medchemie-ENDOTHERM_1_00110.jpg\" alt=\"\" class=\"wp-image-2219\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/medchemie-ENDOTHERM_1_00110.jpg 320w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/medchemie-ENDOTHERM_1_00110-300x225.jpg 300w\" sizes=\"(max-width: 320px) 100vw, 320px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-center has-base-color has-text-color\">Natural products<\/h4>\n\n\n\n<p class=\"has-text-align-center\">Endotherm Life Science Molecules has proven expertise in the synthesis of complex, chiral, natural products. These can be plant ingredients, ...<\/p>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"#naturstoffe\">read more<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-12 wp-block-columns alignfull nopadding lightblue has-base-3-background-color has-background\" id=\"vitamind-diagnostik\">\n<div class=\"is-layout-flow wp-block-column\">\n<div class=\"is-layout-flex wp-container-10 wp-block-columns lightblue\">\n<div class=\"is-layout-flow wp-block-column whitebox nomargin col-5 fullwidth\" style=\"flex-basis:41.666666666667%\">\n<h2 class=\"wp-block-heading\" id=\"vitamind-diagnostik\">Pioneering vitamin D diagnostics require novel reference materials<\/h2>\n\n\n\n<p>Vitamin D is gaining clinical importance in diagnostics. Endotherm Life Science Molecules owns proprietary and patented synthetic methods for the production of more than 35 vitamin D analogs, conjugates, and metabolites. Research-based diagnostics companies use our experience and expertise to develop immunological or LC-MS\/MS-based assays for the diagnosis of vitamin D-dependent diseases.<\/p>\n\n\n\n<ul>\n<li>Stereoselective synthesis<\/li>\n\n\n\n<li>Stable isotope-labeled compounds (<sup>2<\/sup>H- or <sup>13<\/sup>C-labeled)<\/li>\n\n\n\n<li>Labeling at unusual molecular positions and multilabeling<\/li>\n\n\n\n<li>Preparation of reference materials over 20\u201330 synthesis steps<\/li>\n<\/ul>\n\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-7 wp-block-buttons btn left\">\n<div class=\"wp-block-button gradient__btn\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/endotherm-lsm.com\/product-category\/vitamin-d-metabolite\">To the products<\/a><\/div>\n\n\n\n<div class=\"wp-block-button gradient__btn\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/endotherm-lsm.com\/en\/contact\">To the inquiry form<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flow wp-block-column col-5\" style=\"flex-basis:41.7%\">\n<figure class=\"wp-block-image size-large is-resized hex__illu right\"><img decoding=\"async\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x-1024x930.png\" alt=\"\" class=\"wp-image-2148\" width=\"768\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x-1024x930.png 1024w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x-300x273.png 300w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x-600x545.png 600w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x-768x698.png 768w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-big-1@2x.png 1148w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-29 wp-block-columns md__padding\" id=\"wirkstoffe-referenzstandards\">\n<div class=\"is-layout-flow wp-block-column col-5x2\">\n<div class=\"is-layout-flex wp-container-27 wp-block-columns\">\n<div class=\"is-layout-flow wp-block-column\" style=\"flex-basis:83.333333333333%\">\n<div class=\"is-layout-flex wp-container-17 wp-block-columns\">\n<div class=\"is-layout-flow wp-block-column heading\" style=\"flex-basis:100%\">\n<div class=\"is-layout-flex wp-container-15 wp-block-columns plr-30\">\n<div class=\"is-layout-flow wp-block-column hex__heading text\" style=\"flex-basis:66%\">\n<h2 class=\"wp-block-heading\" id=\"wirkstoffe-referenzstandards\">Reference standards for therapeutic drug monitoring<\/h2>\n<\/div>\n\n\n\n<div class=\"is-layout-flow wp-block-column hex__composing--sm\" style=\"flex-basis:33%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"558\" height=\"597\" src=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-small@2x.png\" alt=\"\" class=\"wp-image-2155\" srcset=\"https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-small@2x.png 558w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-small@2x-300x321.png 300w, https:\/\/endotherm-lsm.com\/wp-content\/uploads\/2022\/07\/comp-small@2x-280x300.png 280w\" sizes=\"(max-width: 558px) 100vw, 558px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-23 wp-block-columns plr-30\">\n<div class=\"is-layout-flow wp-block-column col-10 text\">\n<p>Therapeutic drug monitoring (TDM), or measuring patient blood drug levels, is particularly important for correct dosing and avoidance of overdoses of therapeutics with undesirable side effect profiles.<\/p>\n\n\n\n<p>Research-based diagnostics companies engage Endotherm Life Science Molecules to produce (sometimes labeled) compounds to the desired specifications and quantities for use as reference materials for HPLC- or LC-MS\/MS-based TDM. These substances are used in the routine analysis of already approved methods and for the development of new diagnostic methods. Take advantage of our expertise in drug synthesis for the development of new test methods:<\/p>\n<\/div>\n\n\n\n<div class=\"is-layout-flow wp-block-column col-10 text\">\n<ul>\n<li>Stereoselective synthesis<\/li>\n\n\n\n<li>Stable isotope labeled compounds (<sup>2<\/sup>H-, <sup>13<\/sup>C- or <sup>15<\/sup>N-labeled)<\/li>\n\n\n\n<li>Isotope labeling at unusual molecular positions and multilabeling<\/li>\n\n\n\n<li>Cost-effective production of compounds for use as reference materials, including by-products, impurities, and metabolites, at the highest level of purity (&gt;99%) and in some cases over 20\u201330 synthesis steps<\/li>\n\n\n\n<li>Development of new synthetic methods<\/li>\n<\/ul>\n\n\n\n<div class=\"is-layout-flow wp-block-group btn__group\"><div class=\"wp-block-group__inner-container\">\n<div class=\"is-layout-flex wp-block-buttons btn left\">\n<div class=\"wp-block-button gradient__btn text\"><a class=\"wp-block-button__link\" href=\"https:\/\/endotherm-lsm.com\/en\/products\">Go to products<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons btn\">\n<div class=\"wp-block-button gradient__btn text\"><a class=\"wp-block-button__link\" href=\"https:\/\/endotherm-lsm.com\/en\/custom-synthesis\">Make a request<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-25 wp-block-columns\">\n<div class=\"is-layout-flow wp-block-column\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"is-layout-flex wp-container-38 wp-block-columns alignfull sm__padding lightblue has-base-3-background-color has-background\" id=\"naturstoffe\">\n<div class=\"is-layout-flow wp-block-column\">\n<div class=\"is-layout-flex wp-container-36 wp-block-columns lightblue\">\n<div class=\"is-layout-flow wp-block-column iconholder\">\n<div class=\"is-layout-flex wp-container-34 wp-block-columns icon--03\">\n<div class=\"is-layout-flow wp-block-column col-10 offset--1\" style=\"flex-basis:83.333333333333%\">\n<div class=\"is-layout-flex wp-container-32 wp-block-columns md__gap\">\n<div class=\"is-layout-flow wp-block-column whitebox col-10\">\n<h2 class=\"wp-block-heading\" id=\"naturstoffe\">Natural products<\/h2>\n\n\n\n<p>Endotherm Life Science Molecules has outstanding expertise in the synthesis of complex chiral natural products. These can be plant ingredients, steroids or hormones, amino acids or peptides, coenzyme A esters, polyphenols, (amino) glycosides, vitamin D metabolites, (fluorescent) dyes, or other substances derived from nature.<\/p>\n\n\n\n<p>Depending on the requirements, these can be modified by chemical structural modification<\/p>\n\n\n\n<ul>\n<li>to improve the pharmacological profile<\/li>\n\n\n\n<li>for use as biomarkers in metabolism studies<\/li>\n\n\n\n<li>for the development of fluorescence-based assays<\/li>\n<\/ul>\n\n\n\n<p>Furthermore, retinal analogs are successfully used to study light-gated ion channels or receptors in the cutting-edge research field of optogenetics.<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button gradient__btn\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/endotherm-lsm.com\/product-category\/natural-products\">To the products<\/a><\/div>\n\n\n\n<div class=\"wp-block-button gradient__btn\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/endotherm-lsm.com\/en\/contact\">To the inquiry form<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Reference material synthesis Diagnostics companies are constantly challenged with new complex requirements for clinical chemistry, not least due to everchanging and increasingly stringent in vitro diagnostics (IVD) guidelines. For this reason, companies prefer to rely exclusively on contract synthesis companies like Endotherm Life Science Molecules to provide the necessary active ingredients and biomarkers used as &#8230; <a title=\"Clinical chemistry\" class=\"read-more\" href=\"https:\/\/endotherm-lsm.com\/en\/auftragssynthesen\/klinische-chemie\" aria-label=\"Read more about Clinical chemistry\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":27193,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/pages\/27199"}],"collection":[{"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/comments?post=27199"}],"version-history":[{"count":8,"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/pages\/27199\/revisions"}],"predecessor-version":[{"id":58848,"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/pages\/27199\/revisions\/58848"}],"up":[{"embeddable":true,"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/pages\/27193"}],"wp:attachment":[{"href":"https:\/\/endotherm-lsm.com\/en\/wp-json\/wp\/v2\/media?parent=27199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}