Endotherm Documents

 2018

Publications

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine 2018;10:eaan0724. DOI: 10.1126/scitranslmed.aan0724

Patents

US 9,994,508 B2

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES

(United States Patent)

 

Miscellaneous

3rd Compass to Europe´s Innovative Chemical Companies

Endotherm Company Presentation

 2017

Publications

Mohamed, B. A., Kattner, L., Guan, K., Lehnart, S. E., Luther, S.,    Sossalla, S., et al.: The relevant role of SR Ca leak in the development of heart failure.European Journal of Heart Failure 2017; 19(Suppl_1): 343-343.

Kattner L, Bernardi D: An Efficient Synthesis of 1,25-Dihydroxyvitamin D3 LC-Biotin. J Steroid Biochem Mol Biol. 2017;173:89-92.

Kattner L, Volmer DA: Synthesis of Low Abundant Vitamin D Metabolites and Assaying Their Distribution in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) as a New Tool for Diagnosis and Risk Prediction of Vitamin D related Diseases. In: A Critical Evaluation of Vitamin D - Basic Overview, Sivakumar Gowder (editor), Intech publishers, Rijeka. 2017;103-127ISBN 978-953-51-3084-0.

Awards
GHP International Life Sciences Award
Miscellaneous

Short Company Presentation

Flyer: Your partner for vitamin D synthesis

 2016

Publications

Kattner L, Rauch E: Optimization of Chemical Syntheses of Vitamin D C3-Epimers. Anticancer Res 36(3):1417-1422, 2016.

Poster: 19th Vitamin D Workshop, Boston: An Efficient Synthesis of 1,25-Dihydroxyvitamin D3 LC-Biotin

Awards
International Life Sciences Award
Miscellaneous

2nd Compass to Europe´s Innovative Chemical Companies

 2015

Publications

Kattner L, Bernardi D, Rauch E: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products. Anticancer Res 35(2):1205-1210, 2015.

Poster, Symposium “Biological Effects of Light”, Homburg: Optimization of Chemical Syntheses of Vitamin D C3-Epimers

Patent Applications

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (European Patent Application)

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (United States Patent Application)

 2014

Publications

Azimi Hashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF: Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications (5):1-12, 2014.

Patent Applications

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES WO 2014 / 091046 A1

Speech

Workshop: Vitamin D analogues in cancer prevention and therapy, Krefeld: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products

 2013

Publications

Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, Kattner L, El-Armouche A, Eschenhagen Th: Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches. J Biomol Screen 18(8):899-909, 2013.

Bourgonje VJ, Vos MA, Ozdemir S, Doisne N, Acsai K, Varro A, Sztojkov-Ivanov A, Zupko I, Rauch E, Kattner L, Bito V, Houtman M, van der Nagel R, Beekman JD, van Veen TA, Sipido K, Antoons G: Combined Na+/Ca2+ Exchanger and L-Type CalciumChannel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function. Circulation: Arrhythm Electrophysiol. 6:371-379, 2013.

Scholz T, Heyl CL, Bernardi D, Zimmermann S, Kattner L, Klein CD: Chemical, Biochemical and Microbiological Properties of a Brominated Nitrovinylfuran with Broad-Spectrum Antibacterial Activity. Bioorg Med Chem, 21:795-804, 2013.

Patent

Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de ES-2396524_B2

 2012

Publications

Poster EUTrigTreat

 2011

Publications

Poster, Workshop on Vitamin D, Homburg: Development of commercially applicable syntheses of Vitamin D derivatives

Speech

Biotechnologietage München: „Neue Therapieformen: Welche Innovationen und Trends sind zukunftsweisend und –fähig“ 

 2010

Publications

Poster EUGeneHeart

 2009

Publications

Steuer Ch, Heinonen KH, Kattner L, Klein CD: Optimization of assay Conditions for Dengue Virus protease. Effect of various Polyols and Nonionic Detergents. J Biomol Screen. 14(9):1102-1108, 2009.

Poster “Frontiers in Medicinal Chemistry”, Heidelberg: Identification of Lead Compounds for Dengue NS3 Protease Inhibitors

Sotoud H, Kattner L, Eschenhagen Th, El-Armouche A
Colorimetric protein phosphatase inhibition assay for specific detection of phosphatase-inhibitor-1 inhibitory compounds Archiv für Experimentelle Pathologie und Pharmakologie 2009

Awards

nominated for Oskar-Patzelt-Preis

 2008

Publications

Holzer M, Ziegler S, Albrecht B, Kronenberger B, Kaul A, Bartenschlager R, Kattner L, Klein CD, Hartmann RW: Identification of Terfenadine as an Inhibitor of Human CD81-receptor HCV-E2 Interaction: Synthesis and Structure Optimization. Molecules.13:1081-1110, 2008.  

Awards
nominated for Oskar-Patzelt-Preis

 2007

Publications

Outsourcing of medicinal chemistry in the drug discovery process faces CRO´s and pharmaceutical companies with challenges

PharmChem. 2007, July/August, 6-7

 

Awards

Price as “Most Innovative medium-sized company in the Saarland"

nominated for Oskar-Patzelt-Preis