Endotherm Dokumente

 

2021

Flyer: Isotopically Labeled Compounds - Drugs and Vitamin D Metabolites

Firmenpräsentation von GF Dr. Lars Kattner

2020

 

Publikationen

 

Mäder P, Kattner L: Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry. J. Med. Chem. 2020, 63, 23, 14243–14275. doi/10.1021/acs.jmedchem.0c00960

Kattner L, Rauch E: Efficient synthesis of 3-TBDMS-11α,25-dihydroxyvitamin D3 and D2 ethers. J Steroid Biochem Mol Biol. 2020;200: 105638. https://doi.org/10.1016/j.jsbmb.2020.105638

Putkaradze N, König L, Kattner L, Hutter MC, Bernhardt R: Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1. Biochem Biophys Res Commun 2020;524(2):295-300. doi.org/10.1016/j.bbrc.2020.01.091

Kattner L: Recent developments towards the synthesis of vitamin D metabolites. Anticancer Res 2020;40:519-525. doi:10.21873/anticanres.13980

 

Patente

 

EP 2 933 246 B1

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES

(Europäisches Patent)

 

DE 10 2013 107 885 A1

„Biokatalysator zur Produktion von 25-OH-Vitamin D3 und anderen hydroxylierten Vitamin D3 Derivaten mittels rekombinanter Bacillus megaterium Stämme"

(Deutsche Patentanmeldung)

 

EP 3 666 750 A1

CRYSTALLINE FORM OF BEMPEDOIC ACID

(Europäische Patentanmeldung)

 

2019

 

Publikationen

 

Kattner L, Rauch E: Recent developments towards the synthesis of vitamin D metabolites. Anticancer Res 2019;39:3280-3281.

Mäder P: Boron in Medicinal Chemistry: Powerful, but Neglected. CHIMIA International Journal for Chemistry, Volume 73, Numbers 7-8, August 2019, pp. 637-638.

 

Sonstiges

Pressemitteilung UMG 21.03.2019

Lars Kattner präsentiert Endotherm GmbH bei dem 4. Chemistry Partnering in Frankfurt

 2018

Publikationen

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine 2018;10:eaan0724. DOI: 10.1126/scitranslmed.aan0724

Patente

US 9,994,508 B2

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (US-Patent)

Sonstiges
3rd Compass to Europe´s Innovative Chemical Companies

 2017

Publikationen

Mohamed, B. A., Kattner, L., Guan, K., Lehnart, S. E., Luther, S., Sossalla,S., et  al.: The relevant role of SR Ca leak in the development of heart failure.   European  Journal of Heart Failure 2017; 19(Suppl_1): 343-343.

 

Kattner L, Bernardi D: An Efficient Synthesis of 1alpha,25-Dihydroxyvitamin D3 LC-Biotin. J Steroid Biochem Mol Biol. 2017;173:89-92.

 

Kattner L, Volmer DA: Synthesis of Low Abundant Vitamin D Metabolites and Assaying Their Distribution in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) as a New Tool for Diagnosis and Risk Prediction of Vitamin D related Diseases In: A Critical Evaluation of Vitamin D - Basic Overview, Sivakumar Gowder (editor), Intech publishers, Rijeka. 2017;103-127. ISBN 978-953-51-3084-0.

Auszeichnungen
GHP International Life Sciences Award
Sonstiges
Short Company Presentation

Flyer: Your partner for vitamin D synthesis  

 2016

Publikationen
Kattner L, Rauch E: Optimization of Chemical Syntheses of Vitamin D C3-Epimers. Anticancer Res 36(3):1417-1422, 2016.
Poster: 19th Vitamin D Workshop, Boston: An Efficient Synthesis of 1,25-Dihydroxyvitamin D3 LC-Biotin.
Auszeichnungen
International Life Sciences Award
Sonstiges
2nd Compass to Europe´s Innovative Chemical Companies

 2015

Publikationen
Kattner L, Bernardi D, Rauch E: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products. Anticancer Res 35(2):1205-1210, 2015.
Poster, Symposium “Biological Effects of Light”, Homburg: Optimization of Chemical Syntheses of Vitamin D C3-Epimers.

 Patentanmeldungen

VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (Europäische Patentanmeldung)
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (US-Patentanmeldung)

 2014

Publikationen
Azimi Hashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF: Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications (5):1-12, 2014.
Patentanmeldung
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES WO 2014 / 091046 A1
Vortrag
Workshop: Vitamin D analogues in cancer prevention and therapy, Krefeld: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products

 2013

Publikationen
Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, Kattner L, El-Armouche A, Eschenhagen Th: Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches. J Biomol Screen 18(8):899-909, 2013.
Bourgonje VJ, Vos MA, Ozdemir S, Doisne N, Acsai K, Varro A, Sztojkov-Ivanov A, Zupko I, Rauch E, Kattner L, Bito V, Houtman M, van der Nagel R, Beekman JD, van Veen TA, Sipido K, Antoons G: Combined Na+/Ca2+ Exchanger and L-Type CalciumChannel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function. Circulation: Arrhythm Electrophysiol. 6:371-379, 2013.
Scholz T, Heyl CL, Bernardi D, Zimmermann S, Kattner L, Klein CD: Chemical, Biochemical and Microbiological Properties of a Brominated Nitrovinylfuran with Broad-Spectrum Antibacterial Activity. Bioorg Med Chem, 21:795-804, 2013.
Patent
Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de ES-2396524_B2

 2012

Publikationen

 2011

Publikationen
Poster, Workshop on Vitamin D, Homburg: Development of commercially applicable syntheses of Vitamin D derivatives
Vortrag
Biotechnologietage München: „Neue Therapieformen: Welche Innovationen und Trends sind zukunftsweisend und –fähig“

 2010

Publikationen
Poster EUGeneHeart

 2009

Publikationen
Steuer Ch, Heinonen KH, Kattner L, Klein CD: Optimization of assay Conditions for Dengue Virus protease. Effect of various Polyols and Nonionic Detergents. J Biomol Screen. 14(9):1102-1108, 2009.
Poster “Frontiers in Medicinal Chemistry”, Heidelberg: Identification of Lead Compounds for Dengue NS3 Protease Inhibitors.
Sotoud H, Kattner L, Eschenhagen Th, El-Armouche A
Colorimetric protein phosphatase inhibition assay for specific detection of phosphatase-inhibitor-1 inhibitory compounds Archiv für Experimentelle Pathologie und Pharmakologie 2009.
Auszeichnungen
Nominiert für Oskar-Patzelt-Preis
 Vorträge

Pharmaforum: Neue Perspektiven in der Therapie von Herz- und Infektionskrankheiten

 2008

Publikationen
Holzer M, Ziegler S, Albrecht B, Kronenberger B, Kaul A, Bartenschlager R, Kattner L, Klein CD, Hartmann RW: Identification of Terfenadine as an Inhibitor of Human CD81-receptor HCV-E2 Interaction: Synthesis and Structure Optimization. Molecules.13:1081-1110, 2008.       
Auszeichnungen
Nominiert für Oskar-Patzelt-Preis

 2007

Publikationen
Outsourcing of medicinal chemistry in the drug discovery process faces CRO´s and pharmaceutical companies with challenges. PharmChem. 2007, July/August, 6-7.
Auszeichnungen
Preis als “Innovativstes Mitteslständisches Unternehmen des Saarlandes”
Nominiert für Oskar-Patzelt-Preis